Re: [ccp4bb] structure <-> function

- Protein crystallography

Main steps:

- Protein purification
- Crystallisation

Special:

- Programs for crystallography
- X-ray detectors

Basic tutorials:

   - Chemistry
   - Protein
   - Peptide
   - Amino Acids

Xtal community:

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CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999

Previous message:
Subject: structure <-> function
From: Justin Lecher j {- dot -} lecher {- at -} FZ-JUELICH {- dot -} DE
Date: 2009-06-22

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Subject: Re: structure <-> function
From: Roger Rowlett rrowlett {- at -} MAIL {- dot -} COLGATE {- dot -} EDU
Date: 2009-06-22

Subject: Re: structure <-> function
From: Richard Gillilan reg8 {- at -} CORNELL {- dot -} EDU
Date: 2009-06-22

Some years ago, I produced a short computer-animated video (complete
with music and narration) for Jon Clardy's group on chorismate
mutase. The e. coli and b. subtilis forms of chorismate mutase
catalyze the same claisen rearrangement but have completely different
folds and hydrogen bond networks ... convergent evolution I presume.

I have a HUGE Quicktime version of the movie digitized from the
original master tape, but have not taken the time to burn it to DVD
yet. I suppose I should put all my videos on youtube someday. (Also
available as VHS tape). Let me know if you would like a version for
teaching purposes and I'll see if I can burn a copy.

Richard

On Jun 22, 2009, at 6:55 AM, Justin Lecher wrote:

> Hello everxone,
>
> I am looking for an example of two proteins where the primary sequence
> does not show any significant similarities, but which have the same
> function due their structure? I want to use it to demonstrate that
> function could not always deduced from sequence alignments, but from
> structure alignments.
>
> Does anyone could give me some good examples?
>
>
> Thanks Justin
>
>
>
>
> --
> Justin Lecher
> Institute for Neuroscience and Biophysics
> ISB3 - structural biochemistry
> Research Centre Juelich GmbH,
> 52425 Juelich,Germany
> phone: +49 2461 61 5385
>
>

CCP4bb navigation

CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999

Previous message:
Subject: structure <-> function
From: Justin Lecher j {- dot -} lecher {- at -} FZ-JUELICH {- dot -} DE
Date: 2009-06-22

Next message:
Subject: Re: structure <-> function
From: Roger Rowlett rrowlett {- at -} MAIL {- dot -} COLGATE {- dot -} EDU
Date: 2009-06-22