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Re: [ccp4bb] multi-domain protein with identical tertiary structure
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CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999
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Subject: multi-domain protein with identical tertiary structure
From: Shankar Prasad Kanaujia spkanaujia {- at -} GMAIL {- dot -} COM
Date: 2009-07-02		Next message:
Subject: Re: low UV reading on AKTA prime
From: Lijun Liu liulj {- at -} UOXRAY {- dot -} UOREGON {- dot -} EDU
Date: 2009-07-02


Subject: Re: multi-domain protein with identical tertiary structure
From: David Briggs drdavidcbriggs {- at -} GMAIL {- dot -} COM
Date: 2009-07-02

Hi Shankar,

If you mean what I think you mean - yes, hundreds - but it depends on
how strict you are about "identical'

Lots of proteins have repeat domains in them with the same fold (and
homologous sequence) and therefore very similar (if not quite
identical) tertiary structure.

Some examples include; complement factor H (20 CCP domains in a row),
proteins involved in cell motility like Zyxin, TES and Lmo6 (triple
LIM domains), Receptor Tyrosine kinases like RET that have 4
cadherin-like repeats... the list goes on and on.

HTH

David

2009/7/2 Shankar Prasad Kanaujia :
> Dear CCP4 users,
> Is there any multi-domain protein (with at least two domains) which has
> identical tertiary structure of each domain ?
>
> Thanking you.
>
> -regards
> shankar
>
>
>



--
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