Re: [ccp4bb] multi-domain protein with identical tertiary structure

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CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999

Previous message:
Subject: Re: low UV reading on AKTA prime
From: Lijun Liu liulj {- at -} UOXRAY {- dot -} UOREGON {- dot -} EDU
Date: 2009-07-02

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Subject: Re: multi-domain protein with identical tertiary structure
From: Shankar Prasad Kanaujia spkanaujia {- at -} GMAIL {- dot -} COM
Date: 2009-07-02

Subject: Re: multi-domain protein with identical tertiary structure
From: Charlie Bond Charles {- dot -} Bond {- at -} UWA {- dot -} EDU {- dot -} AU
Date: 2009-07-02

Depending on your definition of 'identical', examples of repeated gene
duplication contribute to these:

You could look at glyoxalases where there are dimeric examples where
each monomer is composed of a repeated subdomain (A1-A2:A1-A2) and
monomeric examples where a further duplication has occurred (A1-A2-A3-A4)
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1169964
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1217405

There are also a number of nucleic acid binding proteins which have
strings of domains (e.g. zinc finger or RRM domains)
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1217405
http://www.ncbi.nlm.nih.gov/pubmed/9305981

Depending on your definition of 'domain', pretty much every
repeat-protein (e.g. TPR, WD40 etc) could fall under this category.

Cheers,
Charlie

Shankar Prasad Kanaujia wrote:
> Dear CCP4 users,
> Is there any multi-domain protein (with at least two domains) which has
> identical tertiary structure of each domain ?
>
> Thanking you.
>
> -regards
> shankar
>
>

--
Charlie Bond
Professorial Fellow
University of Western Australia
School of Biomedical, Biomolecular and Chemical Sciences
M310
35 Stirling Highway
Crawley WA 6009
Australia
Charles.Bond@uwa.edu.au
+61 8 6488 4406

CCP4bb navigation

CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999

Previous message:
Subject: Re: low UV reading on AKTA prime
From: Lijun Liu liulj {- at -} UOXRAY {- dot -} UOREGON {- dot -} EDU
Date: 2009-07-02

Next message:
Subject: Re: multi-domain protein with identical tertiary structure
From: Shankar Prasad Kanaujia spkanaujia {- at -} GMAIL {- dot -} COM
Date: 2009-07-02