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Re: [ccp4bb] multi-domain protein with identical tertiary structure
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CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999
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Subject: Re: multi-domain protein with identical tertiary structure
From: Savvas Savvides savvas {- dot -} savvides {- at -} UGENT {- dot -} BE
Date: 2009-07-02		Next message:
Subject: Full-time Research technician position - EMBL Hamburg
From: ccp4spamalot {- at -} YAHOO {- dot -} COM ccp4spamalot {- at -} YAHOO {- dot -} COM
Date: 2009-07-02


Subject: Re: multi-domain protein with identical tertiary structure
From: Partha Chakrabarti ppchak {- at -} GMAIL {- dot -} COM
Date: 2009-07-02

Hi Shankar,

Another fascinating example might be Dscam (Down Syndrome cell adhesion
molecule) with multiple Ig like domains and Fibronectin type III domains.
Different splice isoforms are expressed in different nerves, and it serves
as a recognition module, same repels, different ones attract.

Not all the domains have been solved yet, and looking at the functional
diversity, it is the small differences which are interesting in such case.

There are also examples of "tandem" SH2, FHA, BRCT repeats, but it depends
on how strict you are with the "identical".

Cheers, Partha




On Thu, Jul 2, 2009 at 6:39 AM, Shankar Prasad Kanaujia <
spkanaujia@gmail.com> wrote:

> Dear CCP4 users,
> Is there any multi-domain protein (with at least two domains) which has
> identical tertiary structure of each domain ?
>
> Thanking you.
>
> -regards
> shankar
>
>
>


--
MRC National Institute for Medical Research
Division of Molecular Structure
The Ridgeway, NW7 1AA, UK
Email: pchakra@nimr.mrc.ac.uk
Phone: + 44 208 816 2515

CCP4bb navigation

CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999
Previous message:
Subject: Re: multi-domain protein with identical tertiary structure
From: Savvas Savvides savvas {- dot -} savvides {- at -} UGENT {- dot -} BE
Date: 2009-07-02		Next message:
Subject: Full-time Research technician position - EMBL Hamburg
From: ccp4spamalot {- at -} YAHOO {- dot -} COM ccp4spamalot {- at -} YAHOO {- dot -} COM
Date: 2009-07-02
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