Re: [ccp4bb] multi-domain protein with identical tertiary structure

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CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999

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Date: 2009-07-02

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Subject: Re: multi-domain protein with identical tertiary structure
From: Roger Rowlett rrowlett {- at -} MAIL {- dot -} COLGATE {- dot -} EDU
Date: 2009-07-02

The same is true for Porphyridium purpureum
beta-CA and Halothiobacillus neapolitanus beta-CA. Both are composed of
pseudodimers composed of two structurally homologous domains. In the
case of H. neapolitanus, the domains have very little sequence
homology, and one domain has lost its active site, but not the overall
fold. I suspect there are many examples of this kind of multidomain
chain homology that probably originates from gene duplication events.

Cheers, Roger Rowlett

Phil Jeffrey wrote:

The cadmium-utilizing marine diatom carbonic anhydrase (CA) protein has 
three consecutive CA domains that have very similar structures but 
non-identical sequences.

See:
Structure and metal exchange in the cadmium carbonic anhydrase of marine 
diatoms.
Xu Y, Feng L, Jeffrey PD, Shi Y, Morel FM.
Nature. 2008 Mar 6;452(7183):56-61.

Shankar Prasad Kanaujia wrote:

Dear CCP4 users,
Is there any multi-domain protein (with at least two domains) which has 
identical tertiary structure of each domain ?

Thanking you.

-regards
shankar

CCP4bb navigation

CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999

Previous message:
Subject: low UV reading on AKTA prime
From: Palm palm {- at -} UNI-GREIFSWALD {- dot -} DE
Date: 2009-07-02

Next message:
Subject: Re: Shredded E coli pellets
From: Jacob Keller j-keller2 {- at -} MD {- dot -} NORTHWESTERN {- dot -} EDU
Date: 2009-07-02