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Re: [ccp4bb] A babyish question on coot

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CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999
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Subject: Re: How to determine ligand binding from diffraction pattern?
From: "Gerhardt, Stefan" Stefan {- dot -} Gerhardt {- at -} ASTRAZENECA {- dot -} COM
Date: 2007-05-29
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From: Mark Agacan M {- dot -} Agacan {- at -} DUNDEE {- dot -} AC {- dot -} UK
Date: 2007-05-29


Subject: Re: A babyish question on coot
From: Roberto Steiner roberto {- dot -} steiner {- at -} KCL {- dot -} AC {- dot -} UK
Date: 2007-05-29

Hi Yanming,

I am glad that at least one other person has encountered this problem
so I do not feel too guilty for having asked Paul to do something about
it. Anyway, the MAN was kind enough to add a masking function under the
Extensions Menu. It is something called 'Mask map bla bla..'. (I am not
in the office so I can't read the proper name of the function). It uses
mmdb code to define Chains/atoms/.... that you want to exclude from map
calculations and produces a map masked by them. (For example if all
your metal centres are chain M something like M/* removes all of them).
Very useful imo for refining metal centers at low resolution.

Roberto




Quoting Yanming Zhang :

> Hi,
>
> After JED's email I tried immediately:
> case:
> a metal site which has very strong density and a HIS co-ordinating
> with the ion. After I click 'Real space refine zone' and then the
> residue HIS, the HIS will move to the density which belongs to the
> ion(clash with the ion) no matter how low the weight was set.
>
> PS, I remember that Xfit of XtalView has the beauty to avoid this
> kind of problem, but now I am a regular user of coot.
>
> Thanks
> Yanming
>
>
> On Tue, 29 May 2007, Debreczeni, Judit wrote:
>
>> Unreasonable geometry can be avoided by setting the refinement
>> weight to a lower value -- either using Extensions->Set Matrix
>> (Refinement Weight) or in your .coot file:
>> (set-matrix )
>>
>> There's also a coot-bb, btw.
>>
>> JED
>>
>>
>>
>>
>>
>>
>> -----Original Message-----
>> From: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK]On Behalf Of
>> Yanming Zhang
>> Sent: 29 May 2007 01:50
>> To: CCP4BB@JISCMAIL.AC.UK
>> Subject: [ccp4bb] A babyish question on coot
>>
>>
>> Hi,
>>
>> I use coot almost around the clock. One thing troubles me is that:
>> when clicking on 'real space refine zone', coot seems only care about the
>> 'real space'(Electron density), sometimes it will bring the model to
>> the density no matter whether the density was already claimed by other
>> model atoms or not, resulting in clash and unreasonable geometry. How can
>> I avoid this?
>>
>> Sorry for an old crystallographer to ask so babyish question. But your
>> help can save me lots of time.
>> Thanks
>> Yanming
>>
>



--
Dr. Roberto Steiner
Randall Division of Cell and Molecular Biophysics
New Hunt's House
King's College London
Guy's Campus
London, SE1 1UL
Phone +44 (0)20-7848-8216
Fax +44 (0)20-7848-6435
e-mail roberto.steiner@kcl.ac.uk




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