[ccp4bb] small molecule library

- Protein crystallography

Main steps:

- Protein purification
- Crystallisation

Special:

- Programs for crystallography
- X-ray detectors

Basic tutorials:

   - Chemistry
   - Protein
   - Peptide
   - Amino Acids

Xtal community:

- CCP4BB

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CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999

Previous message:
Subject: Re: fix or scale bfactors during processing?
From: "Edward A {- dot -} Berry" BerryE {- at -} UPSTATE {- dot -} EDU
Date: 2009-10-27

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Subject: PhD Position in Structural Biology, Wuerzburg, Germany
From: Clemens Grimm Clemens {- dot -} Grimm {- at -} BIOZENTRUM {- dot -} UNI-WUERZBURG {- dot -} DE
Date: 2009-10-27

Subject: small molecule library
From: "c {- dot -} weinert" c {- dot -} weinert {- at -} BIOC {- dot -} UZH {- dot -} CH
Date: 2009-10-27

Dear all.

I am looking for a library of small (biologically relevant) compounds to
test binding to a protein. Does somebody know, if there is a company
that sells such a library for fragment based library screening? (to a
reasonable price).

And does anybody has experience with screening such libraries? I assume
that one approach would be soaking the protein with the compounds,
followed by SEC and MS analysis. Anybody tried directly soaking crystals
followed by X-ray analysis?

Thanks alot already in advance for your help.

Sincerely,
Christopher

CCP4bb navigation

CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999

Previous message:
Subject: Re: fix or scale bfactors during processing?
From: "Edward A {- dot -} Berry" BerryE {- at -} UPSTATE {- dot -} EDU
Date: 2009-10-27