[ccp4bb] Another alternative to ChemDraw

- Protein crystallography

Main steps:

- Protein purification
- Crystallisation

Special:

- Programs for crystallography
- X-ray detectors

Basic tutorials:

   - Chemistry
   - Protein
   - Peptide
   - Amino Acids

Xtal community:

- CCP4BB

CCP4bb navigation

CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999

Previous message:
Subject: Re: coot and probe clash
From: "William G {- dot -} Scott" wgscott {- at -} CHEMISTRY {- dot -} UCSC {- dot -} EDU
Date: 2010-02-08

Next message:
Subject: Re: Alternatives to ChemDraw 3D
From: Rotem Sertchook rotem {- dot -} sertchook {- at -} WEIZMANN {- dot -} AC {- dot -} IL
Date: 2010-02-09

Subject: Another alternative to ChemDraw
From: Peter J Stogios p {- dot -} stogios {- at -} UTORONTO {- dot -} CA
Date: 2010-02-08

Coincidentally I was just doing this search myself today. I found a truly great program that is free and is platform-independent since it is based on Java! Enjoy..

http://www.chemaxon.com/product/marvin_land.html

~
Peter J Stogios, Ph.D.

Research Fellow
Structural Proteomics in Toronto
University Health Network
C.H. Best Institute
112 College Street, Room 70
Toronto, Ontario, Canada M5G 1L6
p: 416-978-4033
e: p.stogios@utoronto.ca
w: www.uhnres.utoronto.ca/centres/proteomics

On Feb-8-10, at 7:00 PM, CCP4BB automatic digest system wrote:

> There are 19 messages totalling 3002 lines in this issue.
>
> Topics of the day:
>
> 1. Alternatives to ChemDraw 3D?
> 2. Available Xray diffraction system
> 3. Alternatives to ChemDraw 3D? Yes, Chemdoodle!
> 4. transformation of cell
> 5. Job advertisment: Head of Junior Research Group (tenure track)
> 6. reforigin on 2FKA (3)
> 7. refmac5 and spericity restraints
> 8. Map transformation (3)
> 9. refmac5 and sphericity restraints, 2nd attempt
> 10. Sixth International Workshop on X-ray Radiation Damage to
> Biological,Crystalline Samples, SSRL, 11th-13th March 2010. Registration
> now open.
> 11. problem of imosflm in ccp4 (2)
> 12. coot and probe clash (3)
>
> ----------------------------------------------------------------------
>
> Date: Mon, 8 Feb 2010 16:13:14 +0900
> From: Wataru Kagawa
> Subject: Alternatives to ChemDraw 3D?
>
> Hi all,
>
> I would like to create a pdb file for a chemical compound (FW ~600) that =
> was created in our chemistry department. ChemDraw 3D appears capable of =
> doing this, but I would like to know if there are free alternatives that =
> work great on Macs. Any info would be greatly appreciated.
>
> Thanks.
>
> Wataru
>
>
> ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
> Wataru Kagawa, Ph. D.
> Waseda University
> Graduate School of Advanced Science & Engineering
> 2-2 Wakamatsu-cho, Shinjuku-ku
> Tokyo, Japan 162-8480
> tel. 03-5369-7369 (ext. 3241)
> fax. 03-5367-2820
> ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
>
> ------------------------------
>
> Date: Mon, 8 Feb 2010 08:53:57 +0100
> From: Mattevi Andrea
> Subject: Available Xray diffraction system
>
> Dear CCP4 Community,
>
> our laboratory is going to dismantle an in-house X-ray diffraction
> instrumentation. It consists of a Rigaku RU-200 rotating anode, an
> Osmic Blue confocal system, a RaxisIV++ detector, and an Oxford
> cryostream cooling device. All instruments have been properly
> maintained and are in good working conditions.
>
> If you are interested in this system, please contact me at the address below.
>
> Best regards, Andrea Mattevi
>
>
> --
> Andrea Mattevi
> Dept. Genetics and Microbiology
> University of Pavia
> Via Ferrata 1, 27100 Pavia
> Italy
> Tel. +39-0382-985525/985534
> Fax +39-0382-528496
> Web www.unipv.it/biocry
> Email: andrea.mattevi@unipv.it
>
> ------------------------------
>
> Date: Mon, 8 Feb 2010 12:33:45 +0100
> From: mesters
> Subject: Re: Alternatives to ChemDraw 3D? Yes, Chemdoodle!
>
> Alternatives to ChemDraw 3D? Yes, ChemDoodle!
>
> I installed XDrawChem on Mac OSX 10.4.11 but it crashes all the time=20
> which is somewhat annoying.
>
> Then I finally stumbled upon ChemDoodle *which is not for free* but the=20
> trial version solved my problem at that time.
> Having worked with it, I really liked it so much that I finally=20
> purchased it for 60 US$.
>
> You only pay this amount once, software updates are for free.
>
> Hope this helps.
>
> - Jeroen -
>
> Wataru Kagawa wrote:
>> Hi all,
>>
>> I would like to create a pdb file for a chemical compound (FW ~600) tha=
> t was created in our chemistry department. ChemDraw 3D appears capable of=
> doing this, but I would like to know if there are free alternatives that=
> work great on Macs. Any info would be greatly appreciated.
>>
>> Thanks.
>>
>> Wataru
>>
>>
>> ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
>> Wataru Kagawa, Ph. D.
>> Waseda University
>> Graduate School of Advanced Science & Engineering
>> 2-2 Wakamatsu-cho, Shinjuku-ku
>> Tokyo, Japan 162-8480
>> tel. 03-5369-7369 (ext. 3241)
>> fax. 03-5367-2820
>> ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
>> =20
>
>
> --=20
> Dr. Jeroen R. Mesters
> Gruppenleiter Strukturelle Neurobiologie und Kristallogenese
> Institut f=FCr Biochemie, Universit=E4t zu L=FCbeck
> Zentrum f=FCr Medizinische Struktur- und Zellbiologie
> Ratzeburger Allee 160, D-23538 L=FCbeck
> Tel: +49-451-5004065, Fax: +49-451-5004068
> Http://www.biochem.uni-luebeck.de
> Http://www.iobcr.org
> Http://www.selfish-brain.org
> Http://www.opticryst.org
> --
> If you can look into the seeds of time and say
> which grain will grow and which will not - speak then to me (Macbeth)
> --
>
> ------------------------------
>
> Date: Mon, 8 Feb 2010 12:34:13 +0100
> From: siva charan
> Subject: transformation of cell
>
> Dear All,
>
> Is there a way to transform a cell in Pymol? I want to superimpose cells
> of my two crystal forms, when I use the align command, molecule from one
> unit cell transforms on to other, but the cell stays the same. I just
> want to look if by any chance my cells of two different crystal forms
> are related!!
>
> Thanks
> Siva
>
> ------------------------------
>
> Date: Mon, 8 Feb 2010 12:39:54 +0100
> From: Christine Bentz
> Subject: Job advertisment: Head of Junior Research Group (tenure track)
>
> This is a multi-part message in MIME format.
> --------------040300030302050604070200
> Content-Type: text/plain; charset=ISO-8859-15; format=flowed
> Content-Transfer-Encoding: 7bit
>
> *
> _Job Advertisement _
>
> *The Division of Structural Biology at the Helmholtz Centre for
> Infection Research
> in Braunschweig/Germany invites applications for the position of a
> *Head of Junior Research Group (tenure track)*
>
> Area of research:
> Structural biology
>
> Application:
> The applicants should provide a letter of intent, CV, list of
> publications, list of certificates as well as a short research proposal
> (max. 3 pages).
>
> Prerequisites:
> This call aims for top level postdoctoral fellows, 2 - 5 years after
> they have been conferred their doctorate (child-rearing periods will be
> taken into consideration) who would like to participate in the Helmholtz
> young investigator program (www.helmholtz.de). The candidates must have
> completed a continuous 6-month research period abroad during a doctorate
> or a post-doctorate phase. The most important selection criterion is the
> outstanding quality of the applicants.
>
> Funding:
> Position of group leader, scientific/technical staff plus expenses of
> materials, supplies and investments for 5 years.
>
> For further information please contact
> Prof. Dr. Dirk Heinz, Division of Structural Biology,
> Helmholtz Centre for Infection Research, Braunschweig/Germany,
> dirk.heinz@helmholtz-hzi.de, phone: +49-(0)531-6181-7000
>
> and visit our homepage www.helmholtz-hzi.de/en/research/research_groups/
> structural_biology/
>
> Please contact us if you have any questions!
>
>
> active_dimer_side
>
>
> --------------------------------------------------------
>
> Christine Bentz
> Assistant to Prof. Dr. Dirk Heinz
> Division of Structural Biology
>
> Helmholtz Centre for Infection Research
> Inhoffenstrasse 7
> 38124 Braunschweig / Germany
>
> Fon 0049 (0)531.6181.7002
> Fax 0049 (0)531.6181.7099
>
> --------------------------------------------------------
>
> Protect the environment -
> please don't print this e-mail unless you really need to
>
>
> --------------040300030302050604070200
> Content-Type: multipart/related;
> boundary="------------000701070601060606090904"
>
>
> --------------000701070601060606090904
> Content-Type: text/html; charset=ISO-8859-15
> Content-Transfer-Encoding: quoted-printable
>
>
>
>
>
>
>

> Job Advertisement

>

> The Division of Structural Biology at the Helmholtz Centre for
> Infection Research

> in Braunschweig/Germany invites applications for the position of a

> Head of Junior Research Group (tenure track)

>

> Area of research:=A0=A0=A0=A0=A0=A0=A0=A0

> Structural biology

>

> Application:=A0=A0=A0

> The applicants should provide a letter of intent, CV, list of
> publications, list of certificates as well as a short research proposal
> (max. 3 pages).

>

> Prerequisites:=A0=A0=A0

> This call aims for top level postdoctoral fellows, 2 - 5 years after
> they have been conferred their doctorate (child-rearing periods will be
> taken into consideration) who would like to participate in the
> Helmholtz young investigator program (
> d" href=3D"http://www.helmholtz.de">www.helmholtz.de). The candidates=
>
> must have completed a continuous 6-month research period abroad during
> a doctorate or a post-doctorate phase. The most important selection
> criterion is the outstanding quality of the applicants.

>

> Funding:=A0=A0=A0 =A0=A0=A0

> Position of group leader, scientific/technical staff plus expenses of
> materials, supplies and investments for 5 years.

>

> For further information please contact

> Prof. Dr. Dirk Heinz, Division of Structural Biology,

> Helmholtz Centre for Infection Research, Braunschweig/Germany,

>
> -hzi.de">dirk.heinz@helmholtz-hzi.de, phone: +49-(0)531-6181-7000
>>
>

> and visit our homepage
>
> /en/research/research_groups/">www.helmholtz-hzi.de/en/research/research_=
> groups/ structural_biology/

>

> Please contact us if you have any questions!

>

>

>
> src=3D"cid:part1.07000509.05090207@helmholtz-hzi.de"
> alt=3D"active_dimer_side" v:shapes=3D"Bild_x0020_1" align=3D"left"
> height=3D"254" hspace=3D"12" width=3D"314">

>


> --------------------------------------------------------
> 
> Christine Bentz
> Assistant to Prof. Dr. Dirk Heinz
> Division of Structural Biology=20
> 
> Helmholtz Centre for Infection Research
> Inhoffenstrasse 7
> 38124 Braunschweig / Germany
> 
> Fon  0049 (0)531.6181.7002
> Fax  0049 (0)531.6181.7099
> 
> --------------------------------------------------------
> 
> Protect the environment -=20
> please don't print this e-mail unless you really need to

>
>
>
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> --------------000701070601060606090904--
>
> --------------040300030302050604070200--
>
> ------------------------------
>
> Date: Mon, 8 Feb 2010 13:23:37 -0000
> From: Ian Tickle
> Subject: Re: reforigin on 2FKA
>
> Yes, thanks! I wish I had spotted that before!
>
> As you say Tables 2.2.3.2 (pp 212-213 in my ed.) & 2.2.3.4 (pp 214-215),
> for non-centrosymmetric primitive & centred space groups respectively,
> contain all the authoritative information you need to define the allowed
> origin shifts (as well as info on semi-invariants etc). I think it
> would be useful if all documentation/scripts/programs which claim to
> specify alternate origins etc referenced (and of course were consistent
> with!) these tables.
>
> Cheers
>
> -- Ian
>
>> -----Original Message-----
>> From: George M. Sheldrick [mailto:gsheldr@shelx.uni-ac.gwdg.de]
>> Sent: 05 February 2010 23:08
>> To: Ian Tickle
>> Cc: CCP4BB@JISCMAIL.AC.UK
>> Subject: Re: [ccp4bb] reforigin on 2FKA
>> =20
>> =20
>> I have just noticed that there is a definitive table of equivalent
>> origins for all 230 space groups in volume B of International
>> Tables (in Chapter 2.2 by Carmelo Giacovazzo). This appears to
>> agree with Ian's last email in this thread for the space groups
>> discussed there. It gives the origins directly rather than the
>> Cheshire groups so may be slightly easier to use.
>> =20
>> George
>> =20
>> Prof. George M. Sheldrick FRS
>> Dept. Structural Chemistry,
>> University of Goettingen,
>> Tammannstr. 4,
>> D37077 Goettingen, Germany
>> Tel. +49-551-39-3021 or -3068
>> Fax. +49-551-39-22582
>> =20
>> =20
>> On Wed, 27 Jan 2010, Ian Tickle wrote:
>> =20
>>> Correction: my apologies, I see now that the table of Cheshire
> groups
>>> that I referred to originally came from: Hirshfeld (1968), Acta
> Cryst.
>>> A24, 301-311. I got it from Jorge: it's still good to know that it
> has
>>> Jorge's seal of approval!
>>>
>>> Cheers
>>>
>>> -- Ian
>>>
>>>> -----Original Message-----
>>>> From: owner-ccp4bb@jiscmail.ac.uk
>>>> [mailto:owner-ccp4bb@jiscmail.ac.uk] On Behalf Of Ian Tickle
>>>> Sent: 27 January 2010 22:25
>>>> To: James Holton; Francois Berenger
>>>> Cc: CCP4BB@jiscmail.ac.uk
>>>> Subject: RE: [ccp4bb] reforigin on 2FKA
>>>>
>>>> ... and I was assuming that since it was clear that there are
>>>> omissions
>>>> for F222 and F23 on the CCP4 'alternate origins' page, that
>>>> James' page
>>>> was 100% correct! But I think we have both made the same mistake
> of
>>>> assuming that F222, F23 and F432 all behave identically as
>>>> far as origin
>>>> shifts are concerned.
>>>>
>>>> According to this document:
>>>> http://www.ccp4.ac.uk/dist/html/cheshirecell.html which I
>>>> have no reason
>>>> to question since it comes from an excellent authority (Jorge
> Navaza),
>>>> the Cheshire space group and cell for both F222 and F23 is I
> centred
>>>> (Immm & Im3m resp) with cell lengths a/2, b/2, c/2. This implies
> the
>>>> origin shift (1/4,1/4,1/4), and therefore by unit translations in
> the
>>>> Cheshire lattice (3/4,3/4,3/4) also, is a non-equivalent origin.
> For
>>>> F432 the Cheshire cell is the same as for F222 & F23 but the
> Cheshire
>>>> space group is primitive (Pm3m), which implies that (1/4,1/4,1/4)
> is
>>>> *not* an allowed origin shift, i.e. 'disallowed' in the sense that
> you
>>>> can't use the same SF calculation formula and still expect to get
> the
>>>> right answer: if you're willing to use a different formula
>>>> then anything
>>>> (including completely arbitrary origin shifts, i.e. as in P1) is
>>>> allowed!
>>>>
>>>> So the one redeeming factor from all this is that reforigin at
> least
>>>> appears to give the right answer.
>>>>
>>>> Cheers
>>>>
>>>> -- Ian
>>>>
>>>>> -----Original Message-----
>>>>> From: owner-ccp4bb@jiscmail.ac.uk
>>>>> [mailto:owner-ccp4bb@jiscmail.ac.uk] On Behalf Of James Holton
>>>>> Sent: 27 January 2010 21:35
>>>>> To: Francois Berenger
>>>>> Cc: CCP4BB@jiscmail.ac.uk
>>>>> Subject: Re: [ccp4bb] reforigin on 2FKA
>>>>>
>>>>> Francois Berenger wrote:
>>>>>> It correspond to what is found at the end of James Holton's
>>>>>> origins.com script
>>>>>> http://bl831.als.lbl.gov/~jamesh/pickup/origins.com
>>>>>> so I guess it should be correct.
>>>>> Uhhh...
>>>>>>
>>>>>> He also says how he found them:
>>>>>>
>>>>>> # TABLE OF ALLOWED ORIGIN SHIFTS
>>>>>> These origin shifts were determined emprirically using 100
>>>>>> randomly-placed atoms
>>>>>> that were shifted around with pdbset and checked with SFALL
>>>>> for identical
>>>>>> amplitudes to the 0 0 0 origin. They should be correct for
>>>>> the CCP4
>>>>>> convention
>>>>>> of symmetry. (I.E. R3 and R32 have hexagonal indexing)
>>>>>>
>>>>> Okay, I just went back to my notes on this. I should admit
>>>>> that in my
>>>>> completely brain-dead allowed-origin-shift search described
> above I
>>>>> originally found no "allowed" shifts for F432 (not sure why,
>>>>> but maybe
>>>>> because it was last on my list). Years later, I think it was
>>>>> Peter Zwart
>>>>> who pointed out to me that I was missing a few of what ought to
> be
>>>>> allowed origins. As I recall, at least one of them passed my
>>>>> pdbset/sfall test, so I just assumed I must have done
>>>> something wrong
>>>>> and added everything in the CCP4 document and ITC Vol B to
>>>> the list.
>>>>> For purposes of the origins.com script, I decided to err on
>>>>> the side of
>>>>> having it try things that may or may not work. If it finds
>>>> a match,
>>>>> then great! Right?
>>>>>
>>>>> Perhaps this was not wise of me. I just tried shifting the
>>>> 2fka PDB
>>>>> file by "SHIFT FRAC 0.25 0.25 0.25" with pdbset and comparing
> the
>>>>> resulting Fs from sfall to those of the un-shifted PDB. They
>>>>> are ~30%
>>>>> different. It could be that this is a bug in sfall or pdbset
>>>>> (doubtful), but I would say that pragmatically, this is not
>>>>> an "allowed
>>>>> origin shift" for F432. However, 0,0,0.5 and 0,0.5,0.5 and all
> the
>>>>> other half-cell combinations do work! Guess I missed those!
>>>>> I have now
>>>>> updated my origins.com script. It appears that the allowed
> origin
>>>>> shifts for F432 and F23 are not the same, as I had
>>>> previously thought.
>>>>>
>>>>>>
>>>>>>> plus of course the symmetry-equivalent origins generated
>>>>> from these 4 by
>>>>>>> the space-group centring (F) translations:
>>>>>>>
>>>>>>> 0.0000 0.5000 0.5000
>>>>>>> 0.5000 0.0000 0.5000
>>>>>>> 0.5000 0.5000 0.0000
>>>>>>
>>>>>> I can see these in syminfo.lib.
>>>>>>
>>>>>> However, from what you say, I understand that only 2x3
> possible
>>>>>> origins with each coordinate being 0 or .5 should be accepted
> by
>>>>>> reforigin.
>>>>>> But in my test it accepted all 8 possible combinations of 0
> and .5
>>>>>> that I artificially introduced in my translated test PDBs:
>>>>>>
>>>>>> m@myPS:2fka# grep Frac run.log
sort
uniq
>>>>>> Fractional origin shift: 0.0000 0.0000 0.0000
>>>>>> Fractional origin shift: 0.0000 0.0000 0.5000
>>>>>> Fractional origin shift: 0.0000 0.5000 0.0000
>>>>>> Fractional origin shift: 0.0000 0.5000 0.5000
>>>>>> Fractional origin shift: 0.5000 0.0000 0.0000
>>>>>> Fractional origin shift: 0.5000 0.0000 0.5000
>>>>>> Fractional origin shift: 0.5000 0.5000 0.0000
>>>>>> Fractional origin shift: 0.5000 0.5000 0.5000
>>>>>>
>>>>>> Should I be worried?
>>>>> At this point, I would say no. Reforigin seems to be doing
>>>> it right.
>>>>>
>>>>> I think some of the confusion might be arising because an
>>>> "alternate
>>>>> origin" and a fractional coordinate shift that gives you the
> same
>>>>> structure factor amplitudes may or may not be the same thing.
> Some
>>>>> shifts change the phase, but not the amplitude so whether
>>>> or not they
>>>>> are "alternate" depends on what you are trying to do.
>>>>>
>>>>> -James Holton
>>>>> MAD Scientist
>>>>>
>>>>>>
>>>>>> Thanks,
>>>>>> Francois.
>>>>>>
>>>>>>> So there will be 12 in all, which I think include the ones
> you
>>>>>>> mentioned.
>>>>>>>
>>>>>>> If you're going by
>>>>>>> http://www.ccp4.ac.uk/dist/html/alternate_origins.html
>>>>> then you should
>>>>>>> be aware of a very recent BB discussion in which it was
>>>>> pointed out that
>>>>>>> the entries for F222, F23, F432 and possibly others are
>>>> incomplete.
>>>>>>>
>>>>>>> Eleanor has given me the task of checking & correcting
>>>>> this particular
>>>>>>> documentation, until then don't trust it!
>>>>>>>
>>>>>>> Of course you shouldn't trust reforigin either, just as
>>>>> you shouldn't
>>>>>>> trust any program until you have verified that the results
>>>>> are sensible,
>>>>>>> but I think in this particular the fault doesn't lie with
>>>>> reforigin.
>>>>>>>
>>>>>>> Cheers
>>>>>>>
>>>>>>> -- Ian
>>>>>>>
>>>>>>>> -----Original Message-----
>>>>>>>> From: owner-ccp4bb@jiscmail.ac.uk
>>>>> [mailto:owner-ccp4bb@jiscmail.ac.uk]
>>>>>>> On
>>>>>>>> Behalf Of Francois Berenger
>>>>>>>> Sent: 27 January 2010 06:50
>>>>>>>> To: CCP4BB@JISCMAIL.AC.UK
>>>>>>>> Subject: reforigin on 2FKA
>>>>>>>>
>>>>>>>> Hello,
>>>>>>>>
>>>>>>>> I am playing with ccp4's reforigin to verify some MR
> solutions.
>>>>>>>>
>>>>>>>> If I translate a copy of the pdb.org's PDB 2FKA (from
>>>>> spacegroup F432)
>>>>>>>> by +/-0.5 fractional in any unit cell direction, then
>>>>> reforigin will
>>>>>>>> find back this translation and consider it as valid for this
>>>>>>> spacegroup.
>>>>>>>> But for this spacegroup I should find only (0,0,0) or
>>>>> (1/2,1/2,1/2)
>>>>>>>> as possible alternate origins.
>>>>>>>>
>>>>>>>> Does this mean that I can't trust reforigin and that I
>>>> must filter
>>>>>>>> out its results to retain only the valid ones?
>>>>>>>>
>>>>>>>> Thanks,
>>>>>>>> Francois.
>>>>>>>
>>>>>>>
>>>>>>>
>>>>>>> Disclaimer
>>>>>>> This communication is confidential and may contain privileged
>>>>>>> information intended solely for the named addressee(s). It
>>>>> may not be
>>>>>>> used or disclosed except for the purpose for which it has
>>>>> been sent.
>>>>>>> If you are not the intended recipient you must not review,
> use,
>>>>>>> disclose, copy, distribute or take any action in reliance
>>>>> upon it. If
>>>>>>> you have received this communication in error, please
>>>> notify Astex
>>>>>>> Therapeutics Ltd by emailing I.Tickle@astex-therapeutics.com
> and
>>>>>>> destroy all copies of the message and any attached
>>>>> documents. Astex
>>>>>>> Therapeutics Ltd monitors, controls and protects all its
>>>> messaging
>>>>>>> traffic in compliance with its corporate email policy.
>>>> The Company
>>>>>>> accepts no liability or responsibility for any onward
>>>>> transmission or
>>>>>>> use of emails and attachments having left the Astex
> Therapeutics
>>>>>>> domain. Unless expressly stated, opinions in this message
>>>>> are those
>>>>>>> of the individual sender and not of Astex Therapeutics Ltd.
> The
>>>>>>> recipient should check this email and any attachments for the
>>>>>>> presence of computer viruses. Astex Therapeutics Ltd accepts
> no
>>>>>>> liability for damage caused by any virus transmitted by
>>>>> this email.
>>>>>>> E-mail is susceptible to data corruption, interception,
>>>>> unauthorized
>>>>>>> amendment, and tampering, Astex Therapeutics Ltd only send
> and
>>>>>>> receive e-mails on the basis that the Company is not
>>>>> liable for any
>>>>>>> such alteration or any consequences thereof.
>>>>>>> Astex Therapeutics Ltd., Registered in England at 436
> Cambridge
>>>>>>> Science Park, Cambridge CB4 0QA under number 3751674
>>>>>
>>>>>
>>>>
>>>>
>>>> Disclaimer
>>>> This communication is confidential and may contain privileged
>>>> information intended solely for the named addressee(s). It
>>>> may not be used or disclosed except for the purpose for which
>>>> it has been sent. If you are not the intended recipient you
>>>> must not review, use, disclose, copy, distribute or take any
>>>> action in reliance upon it. If you have received this
>>>> communication in error, please notify Astex Therapeutics Ltd
>>>> by emailing I.Tickle@astex-therapeutics.com and destroy all
>>>> copies of the message and any attached documents.
>>>> Astex Therapeutics Ltd monitors, controls and protects all
>>>> its messaging traffic in compliance with its corporate email
>>>> policy. The Company accepts no liability or responsibility
>>>> for any onward transmission or use of emails and attachments
>>>> having left the Astex Therapeutics domain. Unless expressly
>>>> stated, opinions in this message are those of the individual
>>>> sender and not of Astex Therapeutics Ltd. The recipient
>>>> should check this email and any attachments for the presence
>>>> of computer viruses. Astex Therapeutics Ltd accepts no
>>>> liability for damage caused by any virus transmitted by this
>>>> email. E-mail is susceptible to data corruption,
>>>> interception, unauthorized amendment, and tampering, Astex
>>>> Therapeutics Ltd only send and receive e-mails on the basis
>>>> that the Company is not liable for any such alteration or any
>>>> consequences thereof.
>>>> Astex Therapeutics Ltd., Registered in England at 436
>>>> Cambridge Science Park, Cambridge CB4 0QA under number 3751674
>>>>
>>>>
>>>
>>>
>>> Disclaimer
>>> This communication is confidential and may contain privileged
>> information intended solely for the named addressee(s). It may not be
> used
>> or disclosed except for the purpose for which it has been sent. If you
> are
>> not the intended recipient you must not review, use, disclose, copy,
>> distribute or take any action in reliance upon it. If you have
> received
>> this communication in error, please notify Astex Therapeutics Ltd by
>> emailing I.Tickle@astex-therapeutics.com and destroy all copies of the
>> message and any attached documents.
>>> Astex Therapeutics Ltd monitors, controls and protects all its
> messaging
>> traffic in compliance with its corporate email policy. The Company
> accepts
>> no liability or responsibility for any onward transmission or use of
>> emails and attachments having left the Astex Therapeutics domain.
> Unless
>> expressly stated, opinions in this message are those of the individual
>> sender and not of Astex Therapeutics Ltd. The recipient should check
> this
>> email and any attachments for the presence of computer viruses. Astex
>> Therapeutics Ltd accepts no liability for damage caused by any virus
>> transmitted by this email. E-mail is susceptible to data corruption,
>> interception, unauthorized amendment, and tampering, Astex
> Therapeutics
>> Ltd only send and receive e-mails on the basis that the Company is not
>> liable for any such alteration or any consequences thereof.
>>> Astex Therapeutics Ltd., Registered in England at 436 Cambridge
> Science
>> Park, Cambridge CB4 0QA under number 3751674
>>>
>
>
>
> Disclaimer
> This communication is confidential and may contain privileged information i=
> ntended solely for the named addressee(s). It may not be used or disclosed =
> except for the purpose for which it has been sent. If you are not the inten=
> ded recipient you must not review, use, disclose, copy, distribute or take =
> any action in reliance upon it. If you have received this communication in =
> error, please notify Astex Therapeutics Ltd by emailing I.Tickle@astex-ther=
> apeutics.com and destroy all copies of the message and any attached documen=
> ts.=20
> Astex Therapeutics Ltd monitors, controls and protects all its messaging tr=
> affic in compliance with its corporate email policy. The Company accepts no=
> liability or responsibility for any onward transmission or use of emails a=
> nd attachments having left the Astex Therapeutics domain. Unless expressly=
> stated, opinions in this message are those of the individual sender and no=
> t of Astex Therapeutics Ltd. The recipient should check this email and any =
> attachments for the presence of computer viruses. Astex Therapeutics Ltd ac=
> cepts no liability for damage caused by any virus transmitted by this email=
> . E-mail is susceptible to data corruption, interception, unauthorized amen=
> dment, and tampering, Astex Therapeutics Ltd only send and receive e-mails =
> on the basis that the Company is not liable for any such alteration or any =
> consequences thereof.
> Astex Therapeutics Ltd., Registered in England at 436 Cambridge Science Par=
> k, Cambridge CB4 0QA under number 3751674
>
> ------------------------------
>
> Date: Mon, 8 Feb 2010 06:29:05 -0800
> From: Jan Abendroth

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