[ccp4bb] Partial binding of ligand to multimer

- Protein crystallography

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CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999

Previous message:
Subject: Re: Old High B-Factor Issue
From: Gregg Crichlow gregg {- dot -} crichlow {- at -} YALE {- dot -} EDU
Date: 2007-06-23

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Subject: Re: Partial binding of ligand to multimer
From: Miguel_Ortiz-Lombardía ibdeno {- at -} GMAIL {- dot -} COM
Date: 2007-06-24

Subject: Partial binding of ligand to multimer
From: Michal Harel michal {- dot -} harel {- at -} WEIZMANN {- dot -} AC {- dot -} IL
Date: 2007-06-24

Hi all, We have a structure of a pentamer which was crystallized from
a complex of the protein with a ligand. The structure shows that 4 out
of 5 binding sites are occupied. The symmetry-related molecules pack
much tighter around the unoccupied monomer. I am looking for examples
of structures in which a ligand was "kicked out" of a binding site upon
crystallization.

Regards - Michal.
------------------------------------------------------------------------
Dr. Michal Harel
Dept. of Structural Biology michal.harel@weizmann.ac.il
Weizmann Inst. of Science tel: 972-8-9342647
Rehovot 76100, ISRAEL fax: 972-8-9344159
------------------------------------------------------------------------

CCP4bb navigation

CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999

Previous message:
Subject: Re: Old High B-Factor Issue
From: Gregg Crichlow gregg {- dot -} crichlow {- at -} YALE {- dot -} EDU
Date: 2007-06-23

Next message:
Subject: Re: Partial binding of ligand to multimer
From: Miguel_Ortiz-Lombardía ibdeno {- at -} GMAIL {- dot -} COM
Date: 2007-06-24