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Re: [ccp4bb] R-sleep
 

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CCP4bb <-- 2007 <-- October 2007 <-- 01 October 2007
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Subject: Re: R-sleep
From: Daniel Schlieper daniel {- dot -} schlieper {- at -} TUXOMANIA {- dot -} NET
Date: 2007-10-01 		Next message:
Subject: Morphing with mutations
From: Claudia Scotti claudiascotti {- at -} HOTMAIL {- dot -} COM
Date: 2007-10-02


Subject: Re: R-sleep
From: James Whisstock James {- dot -} Whisstock {- at -} MED {- dot -} MONASH {- dot -} EDU {- dot -} AU
Date: 2007-10-01
Maybe we could invent an R_Schrodinger that hovers in a quantum state untill we peek :)

J

William Scott wrote:>
> If R-sleep is to be the "real" validation R-factor, why not just
> sequester
> each of R-sleep and the current R-free, each as a randomly-chosen (but
> mutually exclusive) set of reflections, and then proceed as normally with
> the other (eg) 80% of the data until the very end of the refinement,
> using
> the R-free set to optimize weightings for geometries, NCS symmetry
> averaging, and so forth, and then simply add those back in at the
> penultimate step of refinement. In the end, you have R-sleep and the
> Rfactor corresponding to the rest of the data, just like before, and you
> can have the additional statistic reporting the difference between
> R-sleep
> and and R-free, which we could call something like the R-i-didn't-peak.
>
>
> Peter Adrian Meyer wrote:
>> This raises a slightly tangential question though - how do we know how
>> what obs/param ratio is good enough?
--
Professor James Whisstock
NHMRC Principal Research Fellow / Monash University Senior Logan fellow

Department of Biochemistry and Molecular Biology
Monash University, Clayton Campus, PO Box 13d, VIC, 3800, Australia
+613 9905 3747 (Phone)
+613 9905 4699 (Fax)
+61 418 170 585 (Mobile)
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