Re: [ccp4bb] Primary source for detergent properties

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From: shi xiaoli sharly78 {- at -} GMAIL {- dot -} COM
Date: 2007-10-24

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Subject: Re: Primary source for detergent properties
From: "Martin {- dot -} Caffrey" martin {- dot -} caffrey {- at -} UL {- dot -} IE
Date: 2007-10-24

Subject: Re: Primary source for detergent properties
From: "R {- dot -} M {- dot -} Garavito" garavito {- at -} MSU {- dot -} EDU
Date: 2007-10-24

Martin,

Yes, I forgot the "bible" of detergents: "Critical micelle
concentrations of aqueous surfactant systems" by Mukerjee and
Mysels. However, the problem with all of these surfactant sources,
including the Surfactant science series mentioned by Sue Roberts, is
that they are focused on the detergents and the properties which are
most useful to applied surfactant research, i.e. making better,
grease-cutting laundry detergents and the like. The detergents we
mostly use in biochemistry are often the unwanted/undesirable
detergents in applied surfactant research. Hence, sifting through a
pile of gravel to find the few flakes of gold takes a lot of time and
patience. Moreover, even if there are data on the detergents we are
interested in, e.g., alkyl glycosides, they are under solvent/solute
conditions that are not useful to biochemists. We do need a database
for biochemistry, but as you say it takes time and money. A Wiki-
style database where users could upload their data might be useful to
the community. I know several Ph.D. theses that contain lots of
information that has never seen the light of day.

Cheers,

Michael

****************************************************************
R. Michael Garavito, Ph.D.
Professor of Biochemistry & Molecular Biology
513 Biochemistry Bldg.
Michigan State University
East Lansing, MI 48824-1319
Office: (517) 355-9724 Lab: (517) 353-9125
FAX: (517) 353-9334 Email: garavito@msu.edu
****************************************************************

On Oct 23, 2007, at 3:50 PM, Martin.Caffrey wrote:

> I have found Bob Laughlin's book 'The Aqueous Phase Behavior of
> Surfactants' to be a useful resource on detergents. It has several
> relevant phase diagrams. Heavy on the P. Chem.
>
> Then there is the mother of all info in the area "Critical micelle
> concentrations of aqueous surfactant systems" a handbook by
> Mukerjee and - you guessed it - Mysels, published in 1971 by the
> National Bureau of Standards. No longer in print, it covers the
> lit from 1926 to the mid-sixties. A lot of useful info in it
> (>5,000 records) including effect of salt, pH and other additives
> on CMC values.
>
> We have converted the contents of the M&M handbook into a
> searchable relational database called the Critical Micelle
> Concentration Database (CMCD). The intent was to update it with
> the latest info on the more commonly used detergents and to post it
> on the web. However, this is a lot of work and requires funding.
> Alas funding for databases is virtually impossible to get. We will
> labor away at it in our 'spare time' and make what we have
> available for general use as soon as it is 'presentable'. Don't
> hold breath.
>
> Martin Caffrey
> University of Limerick
>
>
>

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Previous message:
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Subject: Re: Primary source for detergent properties
From: "Martin {- dot -} Caffrey" martin {- dot -} caffrey {- at -} UL {- dot -} IE
Date: 2007-10-24