[ccp4bb] Postdoctoral Research Associate at Brookhaven National Laboratory

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Subject: Re: how to change a membrane protein into a water soluble protein?
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Subject: Re: how to change a membrane protein into a water soluble protein?
From: Narayanasami Sukumar sukumar {- at -} LILITH {- dot -} NEC {- dot -} APS {- dot -} ANL {- dot -} GOV
Date: 2007-12-04

Subject: Postdoctoral Research Associate at Brookhaven National Laboratory
From: "Allen M {- dot -} Orville" amorv {- at -} BNL {- dot -} GOV
Date: 2007-12-04

POSTDOCTORAL RESEARCH ASSOCIATE -

Project Title: “Novel Methods for Microcrystal Structure
Determination at NSLS and NSLS-II”

Location: Brookhaven National Laboratory, Upton, NY, U.S.A.

This new project is under the direction of A. M. Orville, and is also
associated with the PXRR group
(www.px.nsls.bnl.gov) at
Brookhaven National Laboratory (BNL). The PXRR group conducts
research, technology development, operations, and training at six
beamlines (X8, X12b, X12c, X25, X26c, X29) at the National Synchrotron
Light Source (NSLS). A long-term goal for the PXRR group is to create a
resource for macromolecular crystallography at NSLS-II, the new
synchrotron light source that is being created at BNL during the next
five to seven years.

Microcrystals only a few microns along an edge are often easy to obtain;
but, are typically of no use for traditional diffraction studies. In
contrast, the brightness and focused beam anticipated at NSLS-II provides
an ideal opportunity to use microcrystals for diffraction studies. A
major barrier that remains to be overcome is how to manipulate
microcrystals for structure determination. Part of the research strategy
will be to use a large number of randomly oriented microcrystals, from
each of which only a small fraction of the whole dataset is collected, in
order to build-up the complete dataset. Full expression of these methods
may approach the physical limits of crystal diffraction and will clearly
help motivate the optimum performance of NSLS-II. Consequently, we will
develop novel microcrystallography methods at the NSLS and look forward
to utilizing the outstanding characteristics of NSLS-II facility.

The position requires a Ph.D. in biochemistry, structural biology,
chemistry, or physics. Experience in macromolecular crystallography
and/or synchrotron x-ray sources is desired. The prospective candidate
must be able to interact with a diverse group of scientists and
engineers, as well as work independently. Send CV and contact information
for four mentors or referees to felicia@bnl.gov referring to
Position No. FH4835.

AMO

******

Allen M. Orville, Ph.D.

Biology Department

Brookhaven National Laboratory

Upton, NY 11973-5000

e-mail: amorv@bnl.gov

phone 631-344-4739

fax 631-344-2741

www.biology.bnl.gov/structure/orville.html

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CCP4bb <-- 2007 <-- December 2007 <-- 04 December 2007

Previous message:
Subject: Re: how to change a membrane protein into a water soluble protein?
From: Scott Pegan pegan {- at -} UIC {- dot -} EDU
Date: 2007-12-04