[ccp4bb] postdoc and phd positions available in dna repair

- Protein crystallography

Main steps:

- Protein purification
- Crystallisation

Special:

- Programs for crystallography
- X-ray detectors

Basic tutorials:

   - Chemistry
   - Protein
   - Peptide
   - Amino Acids

Xtal community:

- CCP4BB

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CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999

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Subject: Assistant Researcher position - Crystallography and/or NMR
From: "Maria J {- dot -} Romao" mromao {- at -} DQ {- dot -} FCT {- dot -} UNL {- dot -} PT
Date: 2008-08-05

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Subject: Ph.D. student and Postdoctoral positions in Structural Biology/Biophysics at the Swiss Federal Institute of Technology in Lausanne (EPFL)
From: Petr Leiman leiman {- at -} PURDUE {- dot -} EDU
Date: 2008-08-05

Subject: postdoc and phd positions available in dna repair
From: Joyce Lebbink j {- dot -} lebbink {- at -} ERASMUSMC {- dot -} NL
Date: 2008-08-05

Dear all,

we have several positions available in Structural Biochemistry of DNA
mismatch repair and antirecombination, involving not only X-ray
crystallography but also different single molecule approaches and
biosensor analysis, please see below

Joyce

Positions in Structural Biochemistry of DNA Mismatch Repair and
Antirecombination.

Molecular Radiation Biology, Department of Genetics, Erasmus Medical
Center Rotterdam, The Netherlands.

The Molecular Radiation Biology group focuses on unravelling the
mechanisms that are involved in maintaining genomic stability, in
particular the molecular interactions and structural dynamics that drive
repair of replication errors and DNA breaks. These processes are vital to
cellular survival and important for cancer avoidance. Our approach spans
the experimental range from animal models to single molecule imaging. The
knowledge obtained from this integrated approach has a synergistic effect
on our ability to understand fundamental biological processes.

DNA recombination and repair is carried out by complex pathways in which
multiple proteins cooperate in a precisely defined manner to ensure
correct DNA recognition, repairosome assembly, DNA manipulation and DNA
resynthesis. Mechanistic details of many of these crucial steps are
unknown. Several new projects will be initiated in our lab addressing the
structure of different reaction intermediates and the dynamics of their
formation to determine how structural rearrangements in proteins and DNA
drive consecutive steps in rearrangement and repair processes. Scanning
force microscopy and X-ray structure determination will be used to
visualize protein-DNA complexes. Single molecule fluorescence and
biosensor analysis will provide the dynamics of complex formation and
disassembly. Combined with biochemical activity assays and mutant
analysis, this will contribute to a better understanding of the mechanisms
driving DNA mismatch repair, homologous recombination and the interplay
between these two important cellular pathways.

We have several positions available (Postdoc, PhD, technician). For more
information go to http://web.mac.com/carolwymanmac/Site/Home.html. Do you
have a background in structural biology, single molecule analysis or
biophysics in general and have an interest in multidisciplinary thinking
and research, please ask for more information or send your c.v. with
covering letter and the contact details of three referees to Joyce Lebbink
(j.lebbink@erasmusmc.nl). Please quote CB100.

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CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999