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[ccp4bb] Ph.D. studentship in Structure-based Drug Design, University of Luebeck, Germany |
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CCP4bb navigationCCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999Subject: Ph.D. studentship in Structure-based Drug Design, University of Luebeck, Germany From: Holger Steuber steuber {- at -} BIOCHEM {- dot -} UNI-LUEBECK {- dot -} DE Date: 2008-08-20 Applications are invited for a Ph.D. studentship in the research field of structure-based drug design available at the Institute of Biochemistry, University of Luebeck, Germany. The announced position will be funded for three years by a grant from the Luebeck Graduate School "Computing in Medicine and Life Sciences" (www.gradschool.uni-luebeck.de The Graduate School was established within the scope of the excellence initiative initiated by the German Federal Government and the German Research Foundation (DFG). The Institute of Biochemistry possesses a long-standing reputation for research on the molecular basis of intracellular infections by RNA viruses (particularly coronaviruses including the SARS virus), bacteria and protozoa, with the objective to design and develop new antiinfective drugs (e.g. EMBO J. 21, 3213 (2002), Science 300, 1763 (2003), PNAS 100, 13190 (2003), Cell 117, 57 (2004), JMB 354, 25 (2005), JBC 281, 25425 (2006), Chem Biol 15, 597 (2008)). In the near future, these research activities should be extended to drug targets of disease-relevant flaviviruses, particularly Dengue, West Nile, and Hepatitis C viruses, with special focus on structure-guided design of lead compounds possessing inhibitory activity. The successful candidate will gain experience in a broad variety of experimental and computational techniques such as molecular cloning, recombinant protein expression, purification, crystallization, data collection, structure solution and model building, preparation of protein-ligand complexes, virtual screening for lead- and fragment-like inhibitors, molecular dynamics calculations, biochemical assays, crystallographic fragment screening as well as characterization of protein-ligand interactions by isothermal titration calorimetry. We are building an outstanding program for the discovery of new antiinfectives, with various techniques for preclinical research available in-house. Investigations include the identification of potential virulence proteins by proteomics, crystallization, and X-ray structure determination, as well as the design and chemical synthesis of inhibitors. The institute is well equipped with crystallization facilities such as crystallization robots and imaging systems. We also operate an outstation at DESY (Hamburg) with direct access to synchrotron radiation. Practical basic skills in molecular-biological techniques would be desired. Applicants interested in the announced position are invited to send their complete resumé according to the admission conditions of the Graduate school http://www.gradschool.uni-luebeck.de/?q=node/20) in electronic form to *management@gradschool.uni-luebeck.de -- Dr. Holger Steuber Professor(W1) for Structure-based Drug Design Institute of Biochemistry University of Luebeck Ratzeburger Allee 160 23538 Luebeck Germany Phone : +49-451-500-4065 Fax : +49-451-500-4068 E-mail : steuber@biochem.uni-luebeck.de CCP4bb navigationCCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999 |
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