[ccp4bb] pKa for protein C-terminus?

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CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999

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From: Kornelius Zeth kornelius {- dot -} zeth {- at -} TUEBINGEN {- dot -} MPG {- dot -} DE
Date: 2008-09-05

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Subject: Re: pKa for protein C-terminus?
From: Roger Rowlett rrowlett {- at -} MAIL {- dot -} COLGATE {- dot -} EDU
Date: 2008-09-06

Subject: pKa for protein C-terminus?
From: Patrick Loll pat {- dot -} loll {- at -} DREXEL {- dot -} EDU
Date: 2008-09-05

What value do we expect for the pKa of a protein's C-terminal
carboxylate? pKa values for free amino acids are quite low (2-3),
but it seems to me that this may have something to do with the
proximity of a free amine group; I'd expect a higher value (4-ish?)
for the peptide's C-terminus.

A quick & lazy search using the term "pka" was stymied by a gazillion
references to protein kinase A...

Thanks,
Pat

------------------------------------------------------------------------
---------------
Patrick J. Loll, Ph. D.
Professor of Biochemistry & Molecular Biology
Director, Biochemistry Graduate Program
Drexel University College of Medicine
Room 10-102 New College Building
245 N. 15th St., Mailstop 497
Philadelphia, PA 19102-1192 USA

(215) 762-7706
pat.loll@drexelmed.edu

CCP4bb navigation

CCP4bb <-- 1999 <-- November 1999 <-- 30 November 1999

Previous message:
Subject: Re: Protein Color
From: Kornelius Zeth kornelius {- dot -} zeth {- at -} TUEBINGEN {- dot -} MPG {- dot -} DE
Date: 2008-09-05

Next message:
Subject: Re: pKa for protein C-terminus?
From: Roger Rowlett rrowlett {- at -} MAIL {- dot -} COLGATE {- dot -} EDU
Date: 2008-09-06